Crock Pot Mississippi Meatloaf


  • 1 1/2 lbs ground beef (or a mix of beef and pork)
  • 1 cup breadcrumbs
  • 1/4 cup milk (or unsweetened almond milk for a dairy-free option)
  • 1 large egg
  • 1 packet ranch seasoning mix (about 1 ounce)
  • 1 teaspoon garlic powder
  • 1 teaspoon onion powder
  • Salt and black pepper, to taste

For the Mississippi-Inspired Sauce:

  • 1/2 cup beef broth (or chicken broth)
  • 1/4 cup ranch dressing (optional, for added creaminess)
  • 4 tablespoons butter, sliced
  • 4–6 pepperoncini peppers (adjust to taste)
  • Optional: 1/4 cup pepperoncini juice for extra tang

For Topping:

  • Optional: Shredded cheddar cheese (for melting during the last 10 minutes of cooking)

Step-by-Step Instructions

1. Prepare the Meatloaf Mixture

  1. In a large mixing bowl, combine the ground beef, breadcrumbs, milk, egg, ranch seasoning mix, garlic powder, onion powder, salt, and black pepper.
  2. Mix gently until just combined—avoid overmixing to keep the meatloaf tender.

2. Shape the Meatloaf

  1. Line your slow cooker with parchment paper or a slow cooker liner for easy cleanup.
  2. Shape the meat mixture into a loaf directly in the slow cooker or form it on a cutting board and transfer it to the cooker.

3. Add the Sauce Ingredients

  1. Pour the beef broth (and optional ranch dressing) evenly over the meatloaf.
  2. Place slices of butter on top of the meatloaf for added richness.
  3. Arrange the pepperoncini peppers around the meatloaf. Optional: Drizzle some pepperoncini juice over the top for extra tang.

4. Cook

  1. Cover and cook on low for 6–8 hours or high for 3–4 hours, until the internal temperature of the meatloaf reaches 160°F (71°C).
  2. Optional: During the last 10–15 minutes of cooking, sprinkle shredded cheddar cheese on top of the meatloaf to melt.

5. Serve and Enjoy

  1. Carefully remove the meatloaf from the slow cooker using parchment paper or a spatula.
  2. Slice and serve hot, drizzled with some of the flavorful juices from the bottom of the cooker.
  3. Pair with mashed potatoes, roasted vegetables, or a fresh green salad for a complete meal.

Tips for Success

  • Use Fresh Ingredients: Fresh garlic powder and high-quality ranch seasoning make a noticeable difference.
  • Add Bacon: Wrap the meatloaf in bacon before cooking for extra flavor and a crispy exterior.
  • Make It Spicier: Add extra pepperoncini peppers or a dash of hot sauce for a fiery kick.
  • Freeze for Later: Assemble the raw meatloaf, wrap tightly, and freeze for up to 3 months. Cook directly from frozen, adding 1–2 hours to the cooking time.
  • Switch Proteins: Substitute ground beef with ground turkey or chicken for a lighter twist.

Why This Recipe Works

This Crock Pot Mississippi Meatloaf combines the juicy tenderness of slow-cooked meatloaf with the bold, zesty flavors of Mississippi pot roast. The ranch seasoning, butter, and pepperoncini create a tangy, savory sauce that infuses every bite with incredible flavor. Whether served as a main course or a comforting family dinner, this recipe delivers big on taste and simplicity without requiring advanced cooking skills.

Conclusion: A Dish Everyone Will Love

Whether you’re craving something juicy and indulgent, looking for a way to simplify meatloaf, or simply want to enjoy a comforting slow-cooker meal, this Crock Pot Mississippi Meatloaf is sure to delight. Its bold flavors, creamy textures, and customizable options make it a standout recipe that’s as practical as it is delicious. Plus, its adaptability means you can tailor it to suit any occasion.

We’d love to see your creations! Tag us in your photos or share your favorite variations—your take on this meatloaf might just inspire others to try it too! 🍲✨